Hyphenated Techniques - Chromatography Online
Hyphenated Techniques
LCGC editorial, peer-reviewed research articles, and opinion pieces covering hyphenated chromatographic techniques.

Valves for Gas Chromatography, Part III: Fluidic Switching Applications

November 1, 2011

This month the use of fluidic switching devices for open-tubular column manipulations is discussed.

Analyzing aerosol Defence Pepper Spray Residues on Clothing and Analysis by GC-MS

November 1, 2011

Describes an analysis that was performed in a forensic science laboratory to assess who was the victim and who was the attacker in a legal dispute.

Rapid, Efficient Quantification of Water in Solvents and Solvents in Water Using an Ionic Liquid-based GC Column

October 1, 2011

Describing an accurate analytical technique for the detection and quantification of water using IL-based capillary GC.

GCxGC with Fluidic Modulation on Enantioselective Oil Analysis

October 1, 2011

Describes a novel approach for the enantioselective separation of spearmint oil incorporating a fluidic modulation system.

Phthalate Esters in Toys by GC-MS

September 6, 2011

In this article we look at the determination of phthalate esters in childcare products and children's toys by GC-MS.

Visualizing Complex Samples

September 1, 2011

How does one decipher and tabulate thousands of chemical formulaes and relative abundance without losing the important details.

Ageing Chemistry of Distilled Spirits

September 1, 2011

Describing developments in LC–MS and GC–MS that reveal the ageing chemistry of whiskey aged in oak barrels.

Advances in the Ageing Chemistry of Distilled Spirits Matured in Oak Barrels

September 1, 2011

This article describes the latest developments in LC-MS and GC-MS that reveal the mysteries of this ancient art.

CESI-MS: Metabolic Profiling for Body Fluids

August 22, 2011

Until recently, a promising solution to couple capillary electrophoresis to electrospray ionization mass spectrometry has only been available to a small group of experts.

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LCGC COLUMNISTS 2014

Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration


Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies


MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase


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