Hyphenated Techniques - Chromatography Online
Hyphenated Techniques
LCGC editorial, peer-reviewed research articles, and opinion pieces covering hyphenated chromatographic techniques.

The QuEChERS Revolution

November 1, 2010

Ron Majors interviews the inventors of QuEChERS to explore the sucesses, challenges and future potential of this innovative sample preparation technique.

Evolution of Chromatography: One Scientist's 51-Year Journey

November 1, 2010

Industry veteran Thomas Beesley takes readers on a tour of his experiences in chromatography.

SRM and H-SRM on an Integrated UHPLC-MS Platform

October 8, 2010

Using SRM and H-SRM on an Integrated UHPLC-MS Platform for Sensitive, Accurate and Reproducible Quantification of Perfluorinated Compounds in Human Breast Milk.

Fast GC–MS of Flavours and Fragrances

October 1, 2010

Using narrow-bore column fast GC combined with rapid scanning qMS to analyse flavours and fragrances is described.

The Year of the Laser

September 1, 2010

On the 50th anniversary of the invention of the laser, Michael Balogh examines its importance in MS practice.

Story of a "Recovering" Electrochemist

August 1, 2010

Well-known industry veteran and LCGC EAB member Peter Carr looks back at the early days of the chromatography field and reflects on his own experiences.

Why does it take so long to validate a CDS?

August 1, 2010

The author examines the process of validating a CDS and describes the trials along the way such as speed of validation, risk management, and so forth.

The art of chromatography

July 27, 2010

This summer the National Gallery in London will host an exhibition demonstrating some of the ways that science has been able to shed new light on the history behind some of the Gallery's priceless works of art.

Simultaneous Headspace-GC–FID Analysis

July 1, 2010

An HS-GC-FID method for the determination of ethanol and methanol content in biological fluids is presented.

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LCGC COLUMNISTS 2014

Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration


Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies


MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase


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