Application Notes: Homepage - Chromatography Online
Application Notes: Homepage

Method Development of Mixed-Mode Solid Phase Extraction for Forensics Appliations

November 21, 2014

Read this overview of sample preparation method development using Agilent Bond Elut Certify mixed-mode solid phase extraction to shorten the method development process or to improve an existing method.

Extraction of GHB from Urine Using ISOLUTE® SLE+ Prior to GC/MS

November 21, 2014

This application note describes the extraction of gamma-Hydroxybutyric Acid GHB from urine using supported liquid extraction and subsequent analysis by GC/MS. This method demonstrates a simple extraction protocol with high recoveries and RSDs less than 10%.

Water for GC-MS Analysis of VOCs

November 21, 2014

Analysis of VOCs by P&T GC–MS uses water for the preparation of blanks and standards, as well as for glassware rinsing. To prevent background contamination, this water must be of high purity and free of VOCs. To obtain excellent accuracy and precision of VOC measurements, it is important that the water consistently be of high purity.

Differential Analysis of Olive Oils with Pegasus® GC-HRT and ChromaTOF-HRT® Reference Feature

November 21, 2014

This application demonstrates the use of high resolution GC-TOFMS with industry-leading mass accuracy in the characterization of complex food samples in order to facilitate the detection of food fraud.

Detection of Low-Level Sulfur Compounds in Spearmint Oil

November 21, 2014

Two species of spearmint oil (mentha spicata and mentha gracilis) are cultivated in the United States. In 2008, 1.09 million kilograms of spearmint oil were produced in the U.S. Forty-five percent of mint oil produced in the U.S. is used to flavor chewing gum.

Fast Methods for Structurally Similar Compounds using Carbon HPLC Columns

November 11, 2014

Carbon-clad zirconia phases offer dramatically different chromatographic selectivity for structurally similar compounds when compared to traditional silica-based bonded phases. This note shows baseline separation of 6 structurally similar sulfate-steroid conjugates using a zirconia-based ZirChrom®-CARB HPLC column.

Saccharide tracers in aerosols

October 21, 2014

As a result of the private burning of wood, concentrations of levoglucosan, mannosan, and galactosan in the air are usually increased. An optimum separation and sensitivity of the saccharide markers that accumulate on air filters is achieved on our carbohydrate columns with pulsed amperometric detection. Sample preparation merely requires a simple water extraction.

Rapid detection of chemicals emitted from museum display cases

October 21, 2014

A collaboration between Markes and the German Federal Institute for Materials Research and Testing (BAM) has resulted in a new test scheme, featuring TD–GC–MS sampling & analytical instrumentation, for assessing emissions of artefact-damaging chemicals from the materials used in museum display cases.

Investigation of Synthetic Compounds in Drug Discovery by Integrated HPLC and LC/MS

October 21, 2014

This paper introduces an analysis of eight pharmaceutical substances in a workflow that is typically used for pharmaceutical synthesis confirmation analysis. It describes an example in which measurement was conducted for a range of compounds with properties spanning acidic to basic, and high to low polarity.

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LCGC COLUMNISTS 2014

Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration


Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies


MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase


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