Column: Innovations in HPLC - Chromatography Online
Column: Innovations in HPLC

The Spectro-Electro Array: A Novel Platform for the Measurement of Secondary Metabolites in Botanicals, Supplements, and Beverages

June 1, 2012

HPLC with diode-array and electrochemical-array detection overcomes sensitivity and specificity limitations in natural products analysis.

HPLC Systems and Components Introduced at Pittcon 2012: A Brief Review

April 1, 2012

Highlights of some of the new HPLC and related technology showcased both before and at this year's conference

Nano LC: Principles, Evolution, and State-of-the-Art of the Technique

October 1, 2011

Nano LC is now widely applied in proteomics, and also is robust enough for application in fields such as pharmaceutical analysis.

The Effect of SEC Column Pore Sizes

August 1, 2011

The results of a study to determine the influence of SEC column order on molecular size separation and peak broadening

Pulsed Electrochemical Detection: Waveform Evolution

July 1, 2011

Developments in pulsed electrochemical detection are traced through the progression of its waveforms.

HPLC Systems and Components at Pittcon

May 1, 2011

This year, many HPLC systems focused on facilitating process development, method transfer, and biological analysis.

Seeing is Believing: Detectors for HPLC

October 1, 2010

The principles and attributes of today's HPLC detectors are discussed, and the advantages and disadvantages of the various detectors are compared and contrasted.

Ion Chromatography: An Overview and Recent Developments

July 1, 2010

The basics of IC are reviewed and recent advances that may extend this technology to new applications are discussed.

HPLC Systems and Components Introduced at Pittcon 2010: A Brief Review

May 1, 2010

Michael Swartz presents his first annual review of HPLC systems and accessories at Pittcon 2010.


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Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration

Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies

MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis

LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase

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